Table of half-life of some mRNA and Longevity of some Proteins

mRNA species

Half-life (Hours)









 Protein Species


 β-actin (nonmuscle) 60  crystalline lens protein life of organism (90 yr+)
 Cytochrome P450 36
 Fatty acid synthetase 48-96  hemoglobin life of RBC
 (3 month humans)
 Glu-6-Phosphate dehydrogenase 15
 Glyeraldehyde 3-P dehydrogenase 75-130  Steroid hormone receptor short lived (hours)
 Heat Shock Proteins (70hps) 2.0
 Insulin receptor 9  Casein (milk protein) short lived (hours)
 Pyruvate kinase 30
 Thymidine kinase 2.6  Hsp 70 proteins short lived (hours)
 Tubulin 4 -12
 Tyrosine aminotransferase 2.0  cyclins (cell division) short lived (hours)
 Glucocorticord receptor 2.3
 Ornithine decarboxylase 0.5  transcription factors short lived (hours)
 most bacterial mRNA's < 3.0 minutes