Proteomic Industry Sites
determining 3D protein structure &
integrated relationships of all of a cell's proteins.
Often referred to as structural genomics, this new scientific discipline involves determining the 3-D structures of
large numbers of proteins. The goal of structural proteomics is to reveal the structures of all the key
"functional sites" of any human protein, which should make it much easier to develop highly specific drugs.
|Proteomics & the Proteomics Industry|
|What is Structural Proteomics||How to determine structure|
|Known Protein Structures (3K to date)||Protein Data Bank|
|Protein Structure Prediction||PROSPECT|
|Protein Families||Protein Structure Initiative|
Human Proteomics Initiative
| Individual Species
Genomic Modeling Projects
Eukaryote model organisms
|Proteomics Glossary of Terms||CHI Glossary|
Some projects designed to detect the entire PROTEOME
Some approaches that are being used to analyze all of the proteins being made by genome include:
|The Amersham Pharmacia Inc. ETTAN mass spectrometer offers fast and reliable protein identification for proteomics studies. A single scan over the entire mass range
provides, within minutes, real time data and high resolution spectral scans. The instrument can use a high resolution ion gate and post source decay to analyze protein
fragments. Protein identification and characterization are offered in real time.
|A Proteome Sampler of yeast proteins|
shows 1,458 yeast proteins (circles) and their 1,948 interactions (lines).
Removing proteins has different effects on the yeast: lethal (red);
slowed growth (orange);
Hawoong Jeong and his colleagues at the
Often referred to as structural genomics, this discipline involves determining the 3-D structures of large numbers of proteins, ultimately accounting for an organism's entire proteome. Structural proteomics adds critical information in at least two points in the drug discovery pathway: (1) target identification, or selecting a biochemical pathway in which a drug might function, and (2) medicinal chemistry, or the actual design of compounds to modulate this metabolic pathway.
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