the Nobel Prize in Chemistry for 2006 to Roger D. Kornberg, Stanford University, CA, USA; born 1947 (59) in St Louis, MO, USA (US citizen). PhD from Stanford University, CA, USA. Mrs. George A. Winzer Professor in Medicine at Stanford University School of Medicine, CA, USA. (pic)
                  
"for his studies of the molecular basis of eukaryotic transcription".

   R. Kornberg was the first to create an actual picture of how transcription works at a molecular level in eukaryotes. What Kornberg has done is to describe how the genetic information is copied from DNA into messenger-RNA. The messenger-RNA carries the information out of the cell nucleus so that it can be used to construct the proteins.
   Kornberg's contribution has culminated in his creation of detailed crystallographic pictures describing the transcription apparatus in full action in a eukaryotic cell. In his pictures (all of them created since 2000) one can see the new RNA-strand gradually developing, as well as the role of several other molecules necessary for the transcription process. The pictures are so detailed that separate atoms can be distinguished and this makes it possible to understand the mechanisms of transcription and how it is regulated.      next

 

   Science Magagzine - images of RNA polymerase

   Bil 150 link to movie DNA codes for mRNA, 3D animation.
                                                                                      MyDNAi link -
http://www.dnai.org/lesson/go/19436/

  Original scientific articles (pdf links to these Science articles):
        Cramer, P., Bushnell, D.A. and Kornberg, R.D. (2001) Structural basis of transcription: RNA polymerase II at 2.8 ångstrom resolution.
                Science 292, 1863-1876.  

        Gnatt, A.L., Cramer, P., Fu, J., Bushnell, D.A. and Kornberg, R.D. (2001) Structural basis of transcription: An RNA polymerase II
                elongation complex at 3.3 Å resolution. Science 292, 1876-1882.  

        Bushnell, D.A., Westover, K.D., Davis, R.E. and Kornberg, R.D. (2004) Structural basis of transcription: An RNA polymerase II – TFIIB
                cocrystal at 4.5 angstroms. Science 303, 983-988.